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目的 :探讨手臂振动对血管内皮活性物质的影响及其意义。方法 :应用放射免疫分析 ,对不同接振时间的煤矿掘进工进行血浆内皮素 (ET)、血管紧张素Ⅱ(AngⅡ)、降钙素基因相关肽 (CGRP)的测定 ,并同对照组进行比较分析。结果 :ET、AngⅡ随接振时间延长有明显增高趋势 (p <0 0 5 ,p <0 0 1) ,CGRP随接振时间延长有显著下降趋势 (p <0 0 1)。结论 :手臂振动可导致血管内皮活性物质的改变 ,这种改变可能与振动性血管损伤、振动性白指有一定联系。
Objective: To explore the influence of arm vibration on vascular endothelial active substances and its significance. Methods: Radioimmunoassay was used to measure the levels of plasma endothelin (ET), angiotensin Ⅱ (Ang Ⅱ) and calcitonin gene related peptide (CGRP) in coal miners with different vibration duration and compared with the control group analysis. Results: The levels of ET and AngⅡ increased significantly with the increase of vibration duration (p <0.05, p <0.01). The CGRP decreased significantly with the increase of vibration duration (p <0.01). CONCLUSION: Arm vibration can lead to the change of vascular endothelial active substances. This change may be related to the vibrational vascular injury and vibrational white index.