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目的 观察美托洛尔治疗充血性心力衰竭 (CHF)的临床疗效。方法 选择CHF患者 12 6例 ,随机分为两组 ,对照组常规治疗 ;美托洛尔组在常规治疗基础上加用美托洛尔 ( 12 5～ 10 0mg/d)治疗 ,观察治疗前、治疗后 6个月内的心率、血压、超声心动图及心功能分级变化。结果 与治疗前相比 ,两组心率、左室舒张末期内径、左室射血分数均有明显改善 (P <0 0 1或P <0 0 5 ) ,且美托洛尔组较对照组改善更为明显 (P <0 0 5 )。美托洛尔组心功能改善临床有效率为 85 71% ,显著高于对照组 6 8 2 5 % (P <0 0 5 )。结论 在常规治疗基础上加用美托洛尔可明显改善CHF心功能 ,提高生活质量
Objective To observe the clinical efficacy of metoprolol in the treatment of congestive heart failure (CHF). Methods One hundred and sixty-six patients with CHF were randomly divided into two groups. The patients in the metoprolol group were treated with metoprolol (125 ~ 100 mg / d) on the basis of conventional therapy. Before treatment, Heart rate, blood pressure, echocardiography and cardiac function changes within 6 months after treatment. Results Compared with those before treatment, heart rate, left ventricular end-diastolic diameter and left ventricular ejection fraction were significantly improved in both groups (P <0.01 or P <0.05), and metoprolol improved compared with the control group More obvious (P <0 05). The clinical efficacy of metoprolol improved cardiac function was 85 71%, significantly higher than the control group 6 825% (P lt; 05). Conclusion Adding Metoprolol on the basis of routine treatment can significantly improve the cardiac function and improve the quality of life