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作者将61名Scmplc狂犬病疫苗接种者分为3组,第1组36人,为严重并发症(重症)组,并发症包括脑炎、脊髓炎、多神经炎和脑膜炎;第2组25人,为轻度并发症(轻症)组,并发症有头痛、背肌痛或发热伴注射部位炎症,但脑脊液细胞计数和蛋白含量正常,第3组39人,为无并发症(无症)组。对所有接种者采集血清和脑脊液标本。8份库存健康血清和5例Alzheimer病患者的脑脊液用于对照。用人脑白质和周围神经制备神经抗原。从人脑白质中分离出髓磷脂碱性蛋白。用纯化的人髓磷脂制得髓磷脂相关糖蛋白。脂质提取物经柱层析得到脑苷脂。神经节苷脂使
The authors divided 61 Scmplc rabies vaccine-vaccinated patients into three groups of 36 in the first group, a severe complication of encephalitis, myelitis, polyneuritis and meningitis; Group 2, 25 , Mild complications (mild) group, complications were headache, back muscle pain or fever with inflammation at the injection site, but the cerebrospinal fluid cell count and protein content was normal, 39 patients in group 3, with no complications (asymptomatic) group. Serum and cerebrospinal fluid samples were collected for all vaccinates. Cerebrospinal fluid from 8 healthy stock sera and 5 Alzheimer’s patients was used for the control. Neural antigens were prepared from human white matter and peripheral nerves. Myelin basic protein was isolated from human white matter. Myelin-related glycoproteins were made using purified human myelin. Lipid extracts were subjected to column chromatography to give cerebrosides. Ganglioside