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本项研究采用国产抗-HD ELISA试剂,按双抗体夹心法,待检血清用吐温20处理,观察HBV标志阳性病人血清中HDAg检出率.共检测167例,检出HDAg阳性者14例,总检出率为8.38%,其中以慢性活动型肝炎、肝硬化和慢性迁延型肝炎检出率为高,分别为30.8%、26.7%和16.7%.对血清HBV标志分析发现,HDAg阳性组和阴性组间HBeAg、抗HBe和抗HBc-IgM检出率无显著性差别,而抗HBc-IgA和抗HBc-IgE检出率以阳性组为高,与阴性组对比P<0.05,提示HDAg阳性组患者的肝损较严重.
In this study, domestic anti-HD ELISA reagents were used according to the double antibody sandwich method and the serum to be tested was treated with Tween 20. The detection rate of HDAg in sera of patients with positive HBV markers was detected in 167 cases and 14 cases with HDAg positive , The overall detection rate was 8.38%, of which chronic active hepatitis, cirrhosis and chronic persistent hepatitis detection rate was high, respectively 30.8%, 26.7% and 16.7% .Analysis of serum HBV markers found that HDAg positive group There was no significant difference in the detection rates of HBeAg, anti-HBe and anti-HBc-IgM between the positive and negative groups, while the positive rates of anti-HBc-IgA and anti-HBc-IgE were higher in the positive group than in the negative group Positive group of patients with severe liver damage.