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目的对卵巢原发性类癌进行临床病理观察。方法复习6例原发性卵巢类癌临床病理资料,对部分病例补做免疫组化,并观察分析肿瘤的病理组织学特点。结果患者年龄21～59岁,平均50.7岁;4例为下腹部隐痛,2例为查体发现盆腔肿块。肿瘤位于左侧卵巢4例,右侧2例。肿瘤长径3～6.8 cm,界限清楚,多为实性;瘤细胞呈巢状及小梁状排列。所有病例免疫组化神经内分泌标记CgA和Syn均(+),α-inhabin、CD99、ER、PR、CK7、AFP和TTF-1(-);其中1例黏液型CK20(+),1例巢状型和1例黏液型CDX-2弱(+)。随访13～131个月,5例健在,1例失访。结论原发性卵巢类癌较少见,具有与胃肠道类癌相似的组织学形态,预后良好。
Objective To investigate the clinicopathological features of ovarian primary carcinoid. Methods The clinical and pathological data of 6 primary ovarian cancers were reviewed. The immunohistochemistry was performed on some cases and the histopathological features of the tumors were observed and analyzed. Results The patients were 21-59 years old with an average of 50.7 years old. Four cases had lower abdominal pain and two cases showed pelvic mass. The tumor was located in the left ovary in 4 cases and in the right side in 2 cases. Tumor length of 3 ~ 6.8 cm, clear boundaries, mostly solid; neoplasms nests and trabecular arrangement. All cases were immunohistochemically labeled with neuroendocrine markers CgA and Syn (+), α-inhabin, CD99, ER, PR, CK7, AFP and TTF-1 Type 1 and Mucous CDX-2 Weak (+). Followed up for 13 to 131 months, 5 patients were alive and 1 patient lost their follow-up. Conclusions Primary ovarian carcinoid is rare and has histological morphology similar to that of gastrointestinal carcinoid. The prognosis is good.