现在万古霉素已是一种十分常用的抗生素药物,特别适用于耐二甲氧苯青霉素葡萄球菌引起的急症。在烧伤病人中,使用万古霉素的临床观察与已报道过的在烧伤病人中使用氨基糖苷类抗生素产生的症候相同,即肾排泄随肌酸酐廓清率(CL_(CR))的增加而增加。这种作用的机理尚不清楚。但是已证明了万古霉素在每个烧伤病人中排泄增加。所以,临床上烧伤病人,需要万古霉素的剂量显得比正常人大得多,这样才有可能获得有效的治疗血清浓度。此种情况认为是万古霉素增加肾排泄的效应,因而引起每个病人血管小球过滤速度增加,正如氨基糖苷 Vancomycin is now a very commonly used antibiotics, especially for methicillin-resistant staphylococcal-induced emergency. Clinical observations of vancomycin in burn patients are similar to those reported for the use of aminoglycoside antibiotics in burned patients, where renal excretion increases with increasing creatinine clearance (CL_ (CR)). The mechanism of this effect is not clear. However, vancomycin has been shown to increase excretion in each burn patient. Therefore, the clinical burn patients, the dose of vancomycin appears to be much larger than normal, so that it is possible to obtain effective therapeutic serum concentration. This situation is considered vancomycin to increase the effect of renal excretion, thus causing each patient increased glomerular filtration rate, just as aminoglycoside