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目的:研究骨桥蛋白在卵巢上皮性癌组织中的表达,探讨骨桥蛋白在卵巢上皮性癌侵袭和转移中的作用。方法:采取免疫组织化学SP法检测骨桥蛋白在正常卵巢组织及卵巢良性、交界性、恶性肿瘤组织中的表达。结果:骨桥蛋白在卵巢癌中的表达与肿瘤分化程度、临床分期及有无淋巴结转移相关,与上皮性肿瘤中的不同组织学类型无相关性。结论:骨桥蛋白在正常卵巢组织中不表达,在卵巢上皮性癌中呈高表达,并与临床分期、分级、淋巴结转移有关,提示骨桥蛋白的表达可能与卵巢上皮性癌的发生、发展有关。
OBJECTIVE: To study the expression of osteopontin in epithelial ovarian cancer and to explore the role of osteopontin in invasion and metastasis of ovarian epithelial carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of osteopontin in normal ovarian tissues and ovarian benign, borderline and malignant tumors. Results: The expression of osteopontin in ovarian cancer was correlated with tumor differentiation, clinical stage and lymph node metastasis, but not with histological types in epithelial tumors. CONCLUSION: Osteopontin is not expressed in normal ovarian tissue and overexpressed in epithelial ovarian cancer, which is correlated with clinical stage, grade and lymph node metastasis, suggesting that the expression of osteopontin may be associated with the occurrence and development of ovarian epithelial carcinoma related.