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目的观察埃索美拉唑加阿莫西林、克拉霉素治疗十二指肠球溃疡合并幽门螺杆菌感染的临床疗效。方法将100例幽门螺杆菌阳性十二指肠球溃疡患者随机分为治疗组(n=50)和对照组(n=50),治疗组口服埃索美拉唑、阿莫西林、克拉霉素;对照组口服法莫替丁、阿莫西林、克拉霉素,观察溃疡愈合率、HP清除率和临床症状的改善情况。结果治疗组与对照组的溃疡愈合率、HP根除率、显效率和总有效率比较差异均有统计学意义(P<0.01),两组均无明显副反应。结论联合用药治疗HP阳性的消化性债疡,溃疡愈合率高,疼痛缓解决,且HP根除率和复发率均显著地低于单用埃索美拉唑。
Objective To observe the clinical efficacy of esomeprazole plus amoxicillin and clarithromycin in the treatment of duodenal ulcer complicated with Helicobacter pylori infection. Methods One hundred patients with Helicobacter pylori-positive duodenal ulcer were randomly divided into treatment group (n = 50) and control group (n = 50). The treatment group received oral esomeprazole, amoxicillin, clarithromycin ; The control group oral famotidine, amoxicillin, clarithromycin, observe the ulcer healing rate, HP clearance rate and clinical symptoms improvement. Results The ulcer healing rate, HP eradication rate, markedly effective rate and total effective rate in the treatment group and the control group were significantly different (P <0.01). There was no obvious side reaction in both groups. Conclusions The combined treatment of HP-positive peptic ulcer, ulcer healing rate, pain relief, and the HP eradication rate and recurrence rate were significantly lower than with esomeprazole alone.