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目的研究肝硬化和肝细胞癌患者ＩＬ－２、ｓＩＬ－２Ｒ、ＩＬ－６、Ｔ细胞亚群的变化和相互关系。方法分别采用双抗体夹心ＥＬＩＳＡ法、ＡＢＳ－ＥＬＩＳＡ法和红细胞花环实验，对４６例肝炎肝硬化和肝癌进行了ＩＬ－２、ＩＬ－６、ｓＩＬ－２Ｒ和Ｔ细胞亚群的测定，并与６６例健康献血员进行了对照。结果肝炎肝硬化（ＬＣ）、肝细胞癌（ＨＣＣ）患者血清ＩＬ－２、ＣＤ＋４／ＣＤ＋８水平明显低于正常对照（ＮＣ）组（Ｐ＜００１），而ＩＬ－６、ｓＩＬ－２Ｒ水平明显升高，ＨＣＣ组的平均ＩＬ－６水平高出正常１０倍以上，较肝硬化组明显升高（Ｐ＜００１）。在肝炎肝硬化和肝癌患者均发现ＩＬ－２与ＣＤ＋４／ＣＤ＋８比值、ＩＬ－６与ｓＩＬ－２Ｒ正相关，ＩＬ－６与ＣＤ＋４／ＣＤ＋８比值显著负相关，而与ＩＬ－２无相关关系。结论肝炎肝硬化和肝细胞癌患者存在免疫功能紊乱和低下、淋巴因子网络失衡，这与其病理生理机制有关，也为临床上ＬＣ、ＨＣＣ应用ＩＬ－２治疗提供了理论依据。ＩＬ－６的显著增高有助于ＨＣＣ的早期诊断
Objective To study the changes and correlation of IL-2, sIL-2R, IL-6 and T cell subsets in patients with cirrhosis and hepatocellular carcinoma. Methods The IL-2, IL-6, sIL-2R and T cell subsets of 46 patients with cirrhosis and hepatocellular carcinoma were detected by double antibody sandwich ELISA, ABS-ELISA and erythrocyte rosette respectively. Cases of healthy blood donors were compared. Results The levels of IL-2 and CD 4 / CD 8 in patients with hepatocirrhosis and hepatocellular carcinoma were significantly lower than those in normal controls (P <001), while the levels of IL-6 and sIL-2R (P <0.01). The mean level of IL-6 in HCC group was 10 times higher than that in normal liver cirrhosis group (P <001). The ratio of IL-2 to CD + 4 / CD + 8 was found in patients with liver cirrhosis and hepatocellular carcinoma, IL-6 and sIL-2R were positively correlated, and the ratio of IL-6 and CD + 4 / CD + 8 was negatively correlated but not correlated with IL-2. Conclusions There are immunological disorders and low immune function disorders in patients with liver cirrhosis and hepatocellular carcinoma. The imbalance of lymphokine network is related to its pathophysiological mechanism and provides a theoretical basis for the clinical application of IL-2 in LC and HCC. A significant increase in IL-6 contributes to the early diagnosis of HCC