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Based on the circumfluence situation of the out- and in-Tibet Plateau Vortex (TPV) from 1998-2004 and its weather-influencing system, multiple synthesized physical fields in the middle-upper troposphere of the out- and in-TPV are computationally analyzed by using re-analysis data from National Centers for Environmental Prediction and National Center for Atmospheric Research (NCEP/NCAR) of United States. Our research shows that the departure of TPV is caused by the mutual effects among the weather systems in Westerlies and in the subtropical area, within the middle and the upper troposphere. This paper describes the large-scale meteorological condition and the physics image of the departure of TPV, and the main differences among the large-scale conditions for all types of TPVs. This study could be used as the scientific basis for predicting the torrential rain and the floods caused by the TPV departure.