嗜酸粒细胞增多综合征(Hypereosinophilic Syndrom简称HES)为一少见疾病,临床表现以周围血及骨髓中有嗜酸粒细胞增高,组织中有效成熟的嗜酸粒细胞浸润并可有多系统器官功能障碍为特征。我科于1984年4月收住一例,报告如下: 患者女性,8岁,1984年4月入院。体检时发现全身皮肤有风团样红斑、水疱、脓疮、结节及丘疹坏死性等损害。据云:此类皮损在以往两年中,常于无明显诱因时,无端出现,此起彼落,绵连不断。丘疹坏死后形成深在溃疡,愈后留有萎缩性疤痕。有剧痒常使患者困扰不堪。可自然缓解,亦可无端加重,严重时常伴有发热。虽曾用多种治疗,但均未见效。入院一般检查:体温38.5℃,脉搏120次/分,血压98/50mmHg。发育中等,惟较消瘦。颈部、颌下、双腋窝及腹股沟淋巴结均肿大,小者如豌豆,大者似指头,质硬,可被推动,无压痛。甲状腺与扁桃体均不肿大,咽部微红。胸廓对称,心肺无异常发现。腹平软,肝脏较大,于剑下4厘米,肋下3厘米,质软,无压痛。脾脏亦可于肋下触及。脐周有压痛。肠鸣存在。 Hypereosinophilic Syndrom (Hypereosinophilic Syndrom referred to as HES) is a rare disease, the clinical manifestations of peripheral blood and bone marrow with increased eosinophilia, eosinophils in the organization and effective maturation and may have multiple system organ function Barriers are characterized. My department in April 1984 admitted to a case, the report is as follows: Female patient, 8 years old, admitted in April 1984. Physical examination found that there is wind-like body skin erythema, blisters, abscesses, nodules and papules necrosis and other damage. According to reports: Such lesions in the past two years, often without obvious incentives, unprovoked appearance, one after another, continuous Mianlian. After the papules necrosis deep in the ulcer, the more left after atrophic scars. Itching often distress patients. It can be naturally relieved, can also be exacerbated, often accompanied by severe fever. Although used a variety of treatment, but no effect. General admission examination: body temperature 38.5 ℃, pulse 120 beats / min, blood pressure 98 / 50mmHg. Medium development, but more weight loss. The neck, submandibular, double axillary and inguinal lymph nodes are swollen, the smaller, such as peas, the larger the finger like, hard, can be pushed without tenderness. Thyroid and tonsil are not swollen, throat reddish. Thorax symmetry, no abnormal heart and lung findings. Abdomen soft, larger liver, 4 cm under the sword, rib 3 cm, soft, no tenderness. Spleen can also be reached under the ribs. Umbilical tenderness. Bowel sounds exist.