本文综述了人胚二倍体成纤维细胞的衰老和原癌基因、抑癌基因、细胞周期基因、热休克蛋白基因、延长因子基因及衰老细胞中其他一些基因表达和调控的变化。目前已经阐明的许多基因表达,大部分可能伴随细胞衰老而发生变化,而不是引起细胞衰老的原因。 This review summarizes the changes of human embryonic diploid fibroblasts in senescence and the expression and regulation of some other genes such as proto-oncogene, tumor suppressor gene, cell cycle gene, heat shock protein gene, elongation factor gene and senescent cells. Much of the gene expression that has been elucidated so far, most of which may change with cellular senescence rather than the cause of cell senescence.