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AIM:To evaluate the omeprazole maintenance therapyin patients with recurrent ulcer bleeding after surgery forduodenal ulcer.METHODS:We studied 15 consecutive patients withrecurrent ulcer bleeding after surgery for duodenal ulcer.Omeprazole (20 mg/d) maintenance therapy was givenafter ulcer healing.In addition to clinical follow-up,am-bulatory 24-h gastric pH assay was performed beforeand during omeprazole therapy in those patients andcontrols with previous duodenal ulcer surgery but no ul-cer recurrence.RESULTS:All the 15 ulcers were healed after beingtreated with omeprazole (40 rag/d) for 2 too.Eleven pa-tients with two (1-9) episodes of recurrent ulcer bleedingcompleted the follow-up (43,12-72 mo).None of themhad a bleeding episode while on omeprazole.One patientdiscontinued the therapy and had recurrent bleeding.Themedian 24-h fraction time of gastric pH<4 in patientswas 80,46-95%,and was reduced to 32,13-70% byomeprazole (P=0.002).CONCLUSION:Long-term maintenance therapy withomeprazole (20 mg/day) is effective in preventingrecurrent ulcer bleeding.
AIM: To evaluate the omeprazole maintenance therapyin patients with recurrent ulcer bleeding after surgery for duodenal ulcer. METHODS: We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole (20 mg / d) maintenance therapy was givenafter ulcer healing. to clinical follow-up, am-bulatory 24-h gastric pH assay was performed before and during during methamphetamine therapy in those patients and controls with previous duodenal ulcer surgery but no ul-cer recurrence .RESULTS: All the 15 ulcers were healed after being treated with omeprazole ( 40 rag / d for 2 too. Eleven pa-tients with two (1-9) episodes of recurrent ulcer bleeding compounded the follow-up (43,12-72 mo). Neither of themhad a bleeding episode while on omeprazole. One patientdiscontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH <4 in patients was 80,46-95%, and was reduced to 32,13-70% byomeprazole (P = 0.002) .CONCLUSION: Long-term maintenance therapy withomepra zole (20 mg / day) is effective in preventingrecurrent ulcer bleeding.