下丘脑—垂体—卵巢轴是维持正常排卵周期的中枢,任何导致中枢与末梢功能失调的因素均可引起排卵障碍。 对于闭经的鉴别,首先应测定血中的催乳激素(PRL),如PRL正常则进行黄体酮试验,出现撤退性出血者为Ⅰ度闭经,证明仍具有一定程度的内源性雌激素作用,是克罗米芬疗法的适应证。如给与黄体酮无撤退性出血,而给与雌激素-黄体酮试验出现撤退性出 Hypothalamus - pituitary - ovarian axis is to maintain the normal ovulation cycle center, any cause of central and peripheral dysfunction factors can cause ovulation disorders. For the identification of amenorrhea, the first determination of blood prolactin (PRL), such as PRL normal progesterone test was carried out, who showed withdrawal bleeding degree amenorrhea, to prove that there is still some degree of endogenous estrogen effect is Indications of clomiphene therapy. If no withdrawal bleeding is given to progesterone and withdrawal is given to the estrogen-progesterone test