外阴癌以鳞状细胞癌为主，其病因尚不清楚。主要的致病因素可能为：人乳头瘤病毒（ＨＰＶ）感染，外阴慢性非特异性炎症（如外阴营养不良），其他性传播疾病或病毒感染等〔１〕。近年有学者提出外阴癌多病因学观察〔２～５〕，即外阴癌大体可分两类，一类与ＨＰＶ感染有关，一 Vulvar cancer is mainly squamous cell carcinoma, the etiology is not yet clear. The main risk factors may be: human papillomavirus (HPV) infection, genital chronic non-specific inflammation (such as genital malnutrition), other sexually transmitted diseases or viral infections [1]. In recent years, some scholars have suggested that the etiology of vulvar cancer 〔2 ~ 5〕, that can be divided into two types of vulvar cancer, one related to HPV infection, one