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以培养的新生大鼠心房肌细胞和心室肌细胞为模型,采用放射免疫测定和免疫组织化学法,分别观察了肾上腺素对体外培养的心房和心室肌细胞分泌心钠素的影响。结果表明:肾上腺素(10~(-6)mol/L)不仅促使体外培养新生大鼠心房肌细胞心钠素的分泌,而且刺激心室肌细胞心钠素的分泌。
Using cultured neonatal rat atrial myocytes and ventricular myocytes as models, radioimmunoassay and immunohistochemical methods were used to observe the effects of epinephrine on the secretion of atrial natriuretic peptides from atrial and ventricular myocytes cultured in vitro. The results showed that epinephrine (10-6 mol/L) not only promoted the secretion of atrial natriuretic peptide in neonatal rat atrial myocytes, but also stimulated the secretion of atrial natriuretic peptide from ventricular myocytes.