论文部分内容阅读
目的:研究肾移植术后患者HLA-B*1502基因多态性对环孢素(Cs A)所致肝功能异常的影响。方法:采用PCR-SSP(顺序特异引物聚合酶链反应)方法对339名服用Cs A的肾移植患者进行HLA-B*1502基因多态性检测,根据肾移植患者发生肝脏损伤的情况分为Cs A致肝功异常组、其他原因肝损伤组和对照组。结果:在339名肾移植患者中HLA-B*1502等位基因频率为22.64%。HLA-B*1502多态性在Cs A致肝功异常组、其他原因肝损伤组和对照组三组之间的分布频率差异无统计学意义(P>0.05)。HLA-B*1502基因型组间各临床资料差异均无统计学意义(P>0.05)。结论:HLA-B*1502基因多态性与Cs A所致的肝功异常无明显相关性。
Objective: To investigate the effect of polymorphism of HLA-B * 1502 gene on the abnormal liver function induced by cyclosporine (Cs A) in renal transplant recipients. Methods: HLA-B * 1502 gene polymorphism was detected in 339 kidney transplant recipients with CsA by PCR-SSP (Sequence Specific Primer Polymerase Chain Reaction). According to the liver damage in renal transplant recipients, the patients were divided into Cs A induced liver abnormalities, other causes of liver injury and control group. Results: The frequency of HLA-B * 1502 allele in 339 renal transplant recipients was 22.64%. HLA-B * 1502 polymorphism in CsA-induced liver dysfunction group, other causes of liver injury and control group, the distribution frequency between the three groups showed no significant difference (P> 0.05). HLA-B * 1502 genotypes between the clinical data showed no significant difference (P> 0.05). Conclusion: There is no significant correlation between HLA-B * 1502 polymorphism and CsA-induced abnormal liver function.