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第二代二氢吡啶类钙拮抗剂结构与硝苯吡啶类似,但血管选择性及临床应用更为优越.本文介绍这类新药的特点.尼索地平(Nisoldipine):是一个具有极小电生理和负性肌力效应的强有力的动脉血管扩张剂.对劳力型心绞痛和原发性高血压有一定的疗效,剂量间隔还未确定.对于治疗充血性心力衰竭还有待确证,但初步研究显示出良好的希望.尼卡地平(Nicordipine):是一个有力的末梢血管、脑血管和冠状动脉扩张剂.它引起的心肌机能降低为硝苯吡啶的1/10,在缺血时有重要的心肌保护作用.血液动力学研究证实缺少负性肌力,能减少冠状和末梢血管阻力,对心脏传导效应差,一些对照试验
The second generation of dihydropyridine calcium antagonist structure similar to nifedipine, but the vascular selectivity and clinical application is more superior.This article describes the characteristics of these new drugs.Nisoldipine (Nisoldipine): is a minimal electrophysiological And negative effects of strong arteries on the vasodilator.For labor angina pectoris and essential hypertension have a certain effect, the dose interval has not been determined.For the treatment of congestive heart failure remains to be confirmed, but preliminary studies have shown Good Hope Nicodeipine is a potent peripheral, cerebrovascular and coronary dilator that reduces myocardial performance to nifedipine by a factor of 10 and has important myocardial effects during ischemia Protective effects. Hemodynamic studies confirmed that the lack of negative muscle strength, can reduce coronary and peripheral vascular resistance, the heart conduction effect is poor, some controlled trials