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目的 探讨新生猪缺氧缺血性脑损伤(hypoxicischemicbraindamage,HIBD)时地塞米松对甲状腺功能的影响。方法 在建立新生猪HIBD模型的基础上,对治疗组新生猪使用不同剂量地塞米松(5mg·kg-1·d-1和1mg·kg-1·d-1)共3天,分别于第24小时,第48小时及第72小时采股静脉血收集血清,以放射免疫法(radioimmunoassay,RIA)测定其游离T3(FT3)和游离T4(FT4)浓度。结果 HIBD新生猪FT3、FT4水平较正常对照组降低,其中第48小时差异有显著性(P<005);治疗组FT3、FT4浓度均较HIBD组有所增高。结论 应用地塞米松似能促进或改善HIBD新生猪的甲状腺分泌功能。临床新生儿缺氧缺血性脑病(hypoxicischemicencephalolpathy,HIE)时以使用较小剂量地塞米松为宜。
Objective To investigate the effect of dexamethasone on thyroid function in neonatal hypoxicischemic braindamage (HIBD). Methods Based on the establishment of HIBD model of newborn pigs, dexamethasone (5mg · kg-1 · d-1 and 1mg · kg-1 · d-1) Serum was collected from the femoral vein at 24 hours, 48 hours and 72 hours, and the free T3 (FT3) and free T4 (FT4) concentrations were measured by radioimmunoassay (RIA). Results The levels of FT3 and FT4 in HIBD newborn pigs were lower than those in normal control group, and the difference was significant at the 48th hour (P <0.05). The FT3 and FT4 concentrations in HIBD newborns were higher than those in HIBD group. Conclusion Dexamethasone can promote or improve thyroid secretion in neonatal HIBD pigs. Clinical neonatal hypoxic-ischemic encephalopathy (hypoxicischemicencephalolpathy, HIE) to use a smaller dose of dexamethasone is appropriate.