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除骨髓移植外,以化疗为主的急性白血病治愈率很低,尤其因耐药复发的难治性急性白血病不能治愈的原因是患者体内存在一群具有自我更新能力的白血病干细胞。虽然这些细胞数量极少,但可自我更新,具有很强的增殖潜能,在白血病发生和复发过程中起着关键性作用。白血病干细胞的存在和增殖受细胞表面分子、细胞调控信号通路、细胞自我更新信号通路与骨髓微环境等多因素影响,其中,细胞自我更新信号通路及其相关基因表达在维系白血病干细胞生物学特征方面发挥着重要作用
In addition to bone marrow transplantation, the chemotherapy-based acute leukemia cure rate is very low, especially because of refractory relapse refractory acute leukemia can not be cured because there is a group of patients with self-renewal ability of leukemia stem cells. Although these cells are rare, they are self-renewing and have strong proliferative potential and play a key role in the development and recurrence of leukemia. The existence and proliferation of leukemia stem cells are influenced by many factors such as cell surface molecules, cell regulatory signaling pathway, cell self-renewal signaling pathway and bone marrow microenvironment. Among them, the cell self-renewal signaling pathway and its related gene expression play an important role in maintaining the biological characteristics of leukemia stem cells Play an important role