目的 :通过对诺氟沙星 - PVP共沉淀物的研究 ,为提高难溶性药物溶出度和增大溶解度提供一些参考。方法 :依据药典规定的转篮法 ,以体外溶出度 T5 0 、Td值为考查指标进行优化比较。结果 :优选出诺氟沙星与 PVP的最佳配比为 1∶ 8,并通过 X衍射实验证明诺氟沙星以无定形状态分散在 PVP载体中。结论 :共沉淀物能显著提高诺氟沙星在人工胃液中的溶出度 ,有望达到提高生物利用度的最终目的 OBJECTIVE: To provide some references for improving the dissolution of insoluble drugs and increasing the solubility of norfloxacin-PVP coprecipitates. Methods: According to the Pharmacopoeia basket spinning method, the in vitro dissolution T5 0, Td values ​​for the evaluation index for optimization comparison. Results: The optimal ratio of norfloxacin to PVP was 1: 8, and the results of X-ray diffraction showed that norfloxacin was dispersed in the PVP carrier in amorphous state. Conclusions: Coprecipitate can significantly increase the dissolution of norfloxacin in artificial gastric juice and is expected to achieve the ultimate goal of improving bioavailability