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[目的]探讨5种常见肿瘤标志物(CEA、CA125、CA19-9、CA72-4、AFP)单独与联用时在胃癌诊断中的临床价值。[方法]检测60例胃部良性疾病患者(良性胃病组)和58例胃癌患者(胃癌组)血清肿瘤标志物的水平,比较不同肿瘤标志物单独及联用时的灵敏度和特异度,对各指标的临床价值进行评价。[结果]胃癌组CA125、CA19-9、CA72-4、CEA水平明显高于良性胃病组(P<0.05),2组AFP水平比较差异无统计学意义。采用单项肿瘤标志物诊断胃癌时,灵敏度最高的为CA19-9(36.52%),特异度最高的为CEA(98.12%),ROC曲线下面积最大的为CA19-9(0.953);采用不同肿瘤标志物的联合检测诊断胃癌时,CA19-9+CEA+CA125组合时,灵敏度64.29%,特异度92.59%。[结论]CA19-9+CEA+CA125联合检测能显著提高诊断的灵敏度,具有较好的临床联合检测价值。
[Objective] To investigate the clinical value of five common tumor markers (CEA, CA125, CA19-9, CA72-4, AFP) in the diagnosis of gastric cancer. [Methods] The levels of serum tumor markers in 60 patients with gastric benign disease (benign gastric disease group) and 58 gastric cancer patients (gastric cancer group) were detected. The sensitivity and specificity of different tumor markers alone and in combination were compared. The clinical value of evaluation. [Results] The levels of CA125, CA19-9, CA72-4 and CEA in gastric cancer group were significantly higher than those in benign gastric disease group (P <0.05). There was no significant difference in AFP level between the two groups. When using single tumor markers to diagnose gastric cancer, the highest sensitivity was CA19-9 (36.52%), the highest specificity was CEA (98.12%), and the area under the ROC curve was CA19-9 (0.953). Using different tumor markers Combined detection of gastric cancer, CA19-9 + CEA + CA125 combination, the sensitivity of 64.29%, a specificity of 92.59%. [Conclusion] The combined detection of CA19-9 + CEA + CA125 can significantly improve the diagnostic sensitivity, and has a good clinical value of joint detection.