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多系统萎缩(multiple system atrophy,MSA)是一种散发的进行性神经系统变性疾病,近年来受到国内外神经科学领域临床和基础研究者的广泛关注。MSA 临床表现包括自主神经功能障碍、帕金森综合征、共济失调和锥体系统功能障碍等,病理表现为中枢神经系统多个部位的神经元丢失,少突胶质细胞胞质α-共核蛋白阳性包涵体。根据患者的主要临床表现可将 MSA 分为3种类型:以帕金森症状为主要表现的 MSA-P 型、以小脑共济失调为主要表现的 MSA-C型和以体位性低血压为主要表现的 MSA-A 型(Shy-Drager
Multiple system atrophy (MSA) is a kind of progressive degenerative diseases of the nervous system. In recent years, it has been widely concerned by clinical and basic researchers in the field of neuroscience at home and abroad. MSA clinical manifestations include autonomic dysfunction, Parkinson’s disease, ataxia and pyramidal system dysfunction, the pathological manifestations of neurons in multiple parts of the central nervous system loss, oligodendrocyte cytoplasmic α-common nuclear Protein positive inclusion body. According to the main clinical manifestations of patients, MSA can be divided into three types: MSA-P type with Parkinson’s disease as the main manifestation, MSA-C type with cerebellar ataxia as the main manifestation and orthostatic hypotension as the main manifestation MSA-A type (Shy-Drager