丙戊酸是广谱抗癫疒间药,临床应用广泛。该药体内代谢个体差异大,治疗窗窄,需要个体化治疗。丙戊酸体内代谢受多种因素影响,大量研究报道了丙戊酸群体药代动力学参数及其在个体化治疗中的应用。本文分别从人口学因素、遗传因素及合并用药等方面,对丙戊酸群体药代动力学研究及应用进行综述,为临床制定合理、安全的给药方案提供参考。 Valproic acid is a broad-spectrum anti-epileptic drug, widely used in clinical. The drug body metabolism of individual differences, narrow therapeutic window, the need for individual treatment. Valproic acid metabolism in vivo by a variety of factors, a large number of studies reported valproate population pharmacokinetic parameters and its application in individual therapy. This article reviews the population pharmacokinetics and application of the valproate in terms of demographic factors, genetic factors and drug combinations, respectively, to provide a reference for rational and safe dosing regimen.