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骨桥蛋白(OPN)是一种磷酸化糖蛋白,不仅在卵巢癌及卵巢交界性恶性肿瘤组织中的表达高于在良性肿瘤和正常卵巢上皮组织,而且晚期卵巢癌组织中的表达也明显高于早期癌,在有癌转移的淋巴结中同样高表达。OPN的血清学检查不仅可以用于区别健康人群和卵巢癌患者,还可用于区分卵巢癌和卵巢良性肿瘤。OPN与其他肿瘤标志物联合检测时可以提高卵巢癌的检出率。本文同时还简述了OPN与其他妇科疾病的关系。
Osteopontin (OPN) is a phosphorylated glycoprotein, which is not only expressed in ovarian cancer and borderline ovarian cancers but also in benign tumors and normal ovarian epithelial tissues, as well as in advanced ovarian cancer In early stage cancers, it is equally expressed in lymph nodes with metastases. Serological tests of OPN can not only be used to distinguish between healthy people and patients with ovarian cancer, can also be used to distinguish between ovarian cancer and benign ovarian tumors. OPN and other tumor markers combined detection can improve the detection rate of ovarian cancer. This article also briefly describes the relationship between OPN and other gynecological diseases.