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目的探讨染色质组装因子(CAF-1)p60在非小细胞肺癌中的预后价值,分析其与临床病理特征的相关性。方法连续性选取179例非小细胞肺癌肿瘤组织,采用免疫组化法检测肿瘤组织中CAF-1 p60的表达,分析其与临床病理特征的相关性及预后意义。结果 CAF-1 p60在肺癌组织中为核表达。CAF-1 p60高表达率为47.5%(85/179),低表达率为52.5%(94/179)。CAF-1 p60表达与TNM分期(P<0.001)、肿瘤分化程度(P=0.018)、远处转移(P=0.011)密切相关。KaplanMeier生存曲线提示,CAF-1 p60高表达患者的生存率明显低于低表达者(P<0.001)。Cox多变量生存分析提示,CAF-1 p60高表达是重要的独立预后因素(HR=2.747,P=0.001)。结论在非小细胞肺癌中,CAF-1 p60高表达提示预后不良,并且与肿瘤分期、分级及远处转移相关。CAF-1 p60可以作为非小细胞肺癌的独立预后因子。
Objective To investigate the prognostic value of chromatin assembly factor (CAF-1) p60 in non-small cell lung cancer (NSCLC) and to investigate its relationship with clinicopathological features. Methods 179 cases of non-small cell lung cancer tissues were selected continuously. The expression of CAF-1 p60 in tumor tissue was detected by immunohistochemical method. The correlation between the expression of CAF-1 and clinical pathological features and the prognostic significance were analyzed. Results CAF-1 p60 was nuclear in lung cancer. The high expression rate of p60 in CAF-1 was 47.5% (85/179), and the low expression rate of p60 was 52.5% (94/179). The expression of p60 in CAF-1 was closely related to TNM staging (P <0.001), tumor differentiation (P = 0.018) and distant metastasis (P = 0.011). KaplanMeier survival curves suggested that the survival rate of patients with high expression of p60 in CAF-1 was significantly lower than that in patients with low expression of p60 (P <0.001). Cox multivariate survival analysis suggested that high expression of p60 in CAF-1 was an important independent prognostic factor (HR = 2.747, P = 0.001). Conclusions In non-small cell lung cancer, high expression of p60 in CAF-1 suggests poor prognosis and is associated with tumor stage, grade and distant metastasis. CAF-1 p60 is an independent prognostic factor for non-small cell lung cancer.