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文献报道山金车(Arnica montana)和多叶山金车(A. chamissonis ssp. foliosa)花中含0.4％～0.6％的黄酮类。本文从这2种植物中分离出21种黄酮和5种倍半萜内酯,并采用微培养四唑(MTT)法,检验了这26种化合物对GLC_4(人小细胞肺癌细胞株)和COLO320(人结肠直肠癌细胞株)的细胞毒性。通过持续培养,大部分黄酮呈现中度至低度的细胞毒性,并与参照物顺氯氨铂(其对GLC_4和COLO320的IC_(50)分别为1.1μM和
The literature reports that Arnica montana and A. chamissonis ssp. foliosa flowers contained 0.4% to 0.6% of flavonoids. In this paper, 21 flavonoids and 5 sesquiterpene lactones were isolated from these two plants, and these 26 compounds were tested against GLC_4 (human small cell lung cancer cell line) and COLO320 using a micro-cultured tetrazolium (MTT) method. (human colorectal cancer cell line) cytotoxicity. Through continuous culture, most of the flavonoids exhibited moderate to low cytotoxicity and were referenced to cisplatin (the IC_(50) for GLC_4 and COLO320 was 1.1 μM and