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帕金森病是一种常见的中老年性神经变性病,主要表现为运动症状和非运动症状。临床中随着抗帕金森药物的应用,运动症状得到有效改善,非运动症状逐渐成为影响患者生活质量的主要因素。在非运动症状中,消化系统功能紊乱,如流涎、吞咽困难、胃排空延迟、便秘等最常见,并严重影响患者的生活质量。临床上药物治疗消化系统功能紊乱效果差。本文就国内外对帕金森病消化系统功能紊乱的发病机制、诊断、治疗等方面的研究做一综述。
Parkinson’s disease is a common middle-aged neurodegenerative disease, mainly manifested as motor symptoms and non-motor symptoms. With the clinical application of anti-Parkinson drugs, motor symptoms have been effectively improved, non-motor symptoms gradually become the main factor affecting the quality of life of patients. In non-motor symptoms, digestive system disorders such as salivation, dysphagia, delayed gastric emptying, constipation and the most common, and seriously affect the quality of life of patients. Clinical drug treatment of digestive system dysfunction is poor. This article reviews the research on the pathogenesis, diagnosis and treatment of dysfunction of digestive system in Parkinson’s disease at home and abroad.