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目的 观察支气管哮喘患者发作期与缓解期血浆心钠素水平的变化。方法 采用放射免疫分析方法，测定３６ 例支气管哮喘发作期与缓解期患者，２０ 例慢性支气管炎急性发作期患者血浆心钠素（ＡＮＦ） 水平。结果 ３６ 例支气管哮喘患者发作期ＡＮＦ明显高于缓解期，ＡＮＦ分别是２８７－８７±１４１－０３ 与１９０－０３±９４－０８ ｎｇ／Ｌ（ Ｐ＜ ０－０１） 。其中，６ 例ＰａＯ２ ＜８ ｋＰａ，ＡＮＦ为４０８－９０±１４２－２０ ｎｇ／Ｌ，其余３０ 例ＰａＯ２＞ ８ ｋＰａ，ＡＮＦ为２９９－７９ ±１４１－７６ ｎｇ／Ｌ，两者具有显著性差异（Ｐ＜０－０１） 。支气管哮喘发作期与慢支急性发作期ＡＮＦ均明显高于对照组，ＡＮＦ分别是２８７－８７±１４１－０３、２８９－１０±１６２－６３ ｎｇ／Ｌ及１６７－６３±９４－０８ ｎｇ／Ｌ（ Ｐ＜０－０１），但两组之间无显著性差异。结论 血浆心钠素水平在支气管哮喘发作期升高，并与其病情严重程度有关。
Objective To observe the changes of plasma atrial natriuretic peptide in patients with bronchial asthma at the onset and remission. Methods The levels of plasma atrial natriuretic peptide (ANF) in 36 patients with exacerbation and remission of bronchial asthma and 20 patients with acute exacerbation of chronic bronchitis were determined by radioimmunoassay. Results The ANF in 36 patients with bronchial asthma was significantly higher than that in remission. The ANF were 287-87 ± 141-03 and 190-03 ± 94-08 ng / L, respectively (P <0-01). There were 6 cases of PaO2 <8 kPa, ANF of 408-90 ± 142-20 ng / L, the remaining 30 cases of PaO2> 8 kPa and ANF of 299-79 ± 141-76 ng / L, with significant difference P <0-01). The ANF of bronchial asthma and acute exacerbation of chronic bronchitis were significantly higher than that of the control group, the ANF were 287-87 ± 141-03,289-10 ± 162-63 ng / L and 167-63 ± 94-08 ng / L (P <0-01), but no significant difference between the two groups. Conclusion Plasma atrial natriuretic peptide levels are elevated during the onset of bronchial asthma and are related to the severity of the disease.