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目的研究胎儿生长受限(Fetal growth restriction,FGR)时胎盘生长因子(Placenta growth factor,PLGF)、可溶性血管内皮生长因子受体-1(Soluble fms-like tyrosine kinase-1,sFlt-1)在胎盘组织中的表达。方法应用逆转录聚合酶链式反应(RT-PCR)检测30例胎儿生长受限孕妇和50例正常妊娠妇女胎盘中PLGF、sFlt-1的表达。结果 PLGF、sFlt-1 mRNA在两组胎盘中均有表达,PLGF在FGR组的表达明显低于对照组的表达分别为(20.57±2.1)、(25.95±3.68),两者差异有显著性(P<0.05).sFlt-1 mRNA在FGR组的表达明显高于对照组的表达分别为(32.36±3.13)、(27.25±3.34),差异有显著性(P<0.05)。结论 PLGFmRNA在胎儿生长受限患者胎盘组织表达降低,sFlt-1 mRNA表达升高,可能对胎儿生长受限的发病机制有一定的作用。
Objective To investigate the effect of placenta growth factor (PLGF) and soluble vascular endothelial growth factor receptor-1 (sFlt-1) on the placenta in Fetal growth restriction (FGR) Expression in tissue. Methods The expression of PLGF and sFlt-1 in placenta of 30 pregnant women with fetal growth restriction and 50 normal pregnant women were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results The expressions of PLGF and sFlt-1 mRNA in both groups of placenta were significantly higher than those in control group (20.57 ± 2.1, 25.95 ± 3.68, respectively) P <0.05). The expression of sFlt-1 mRNA in FGR group was significantly higher than that in control group (32.36 ± 3.13, respectively, 27.25 ± 3.34, P <0.05). Conclusion The expression of sFlt-1 mRNA in placenta of patients with limited fetal growth is decreased and the expression of sFlt-1 mRNA is increased, which may play a role in the pathogenesis of fetal growth restriction.