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目的:探讨替吉奥联合顺铂治疗胃癌的疗效、生存质量和毒副反应。方法:将104例患者随机分为两组,对照组52例,采用5-氟尿嘧啶(5-FU)加顺铂进行化疗,5-Fu500mg·m2,持续静点dl～d5;顺铂80～100mg·m2加入生理盐水250ml中,分2～3d静滴;治疗组采用替吉奥胶囊加顺铂进行化疗,替吉奥胶囊40mg/次,2次/d,顺铂80～100mg·m2加入生理盐水250ml中,分2～3d静滴。治疗3个周期后,疗结束后对其近期有效率、疾病控制率、疾病进展时间、中位生存时间、1年生存率和毒副反应进行评价。结果:实验组和对照组有效率和疾病控制率分别为63.46%、82.69%和42.31%、69.23%。与对照组相比较,治疗组生活质量和生存率明显提高。治疗组的毒副反应(骨髓抑制和消化道反应)明显下降。结论:替吉奥胶囊联合顺铂方案治疗胃癌的近期疗效较好,不良反应可以耐受,值得进一步研究应用。
Objective: To investigate the curative effect, quality of life and toxicities and side effects of treatment of gastric cancer with tiotropium and cisplatin. Methods: One hundred and four patients were randomly divided into two groups, control group (n = 52), chemotherapy with 5-fluorouracil (5-FU) plus cisplatin, · M2 added 250ml of normal saline, intravenous infusion of 2 ~ 3d; the treatment group was treated with getino capsule plus cisplatin, for the treatment of georg capsule 40mg / time, 2 times / d, cisplatin 80 ~ 100mg · m2 added physiology Saline 250ml, 2 ~ 3d intravenous infusion. After three cycles of treatment, the efficacy, disease control rate, disease progression time, median survival time, 1 year survival rate and toxicity were evaluated after treatment. Results: The effective rate and disease control rate of experimental group and control group were 63.46%, 82.69% and 42.31%, 69.23% respectively. Compared with the control group, the treatment group significantly improved the quality of life and survival. Toxic side effects (myelosuppression and gastrointestinal reactions) in the treatment group decreased significantly. CONCLUSION: The short-term curative effect of TIGO capsule combined with cisplatin on gastric cancer is good and the side effects can be tolerated. It is worth further study and application.