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目的:探讨结直肠癌患者血清基质金属蛋白酶水平及其临床意义。方法:采用Bio-plex200悬浮芯片系统检测33例结直肠癌患者(其中13例为结直肠癌转移患者,20例为结直肠癌非转移组)和30例正常对照组血清中基质金属蛋白酶(MMP)-1、2、3、7、8、9、10、12、13的浓度。结果:与正常对照组相比,结直肠癌患者血清MMP-2、MMP-7、MMP-8、MMP-9、MMP-10、MMP-13的浓度显著上调(P<0.05),而MMP-1、MMP-3、MMP-12的浓度并无显著性差异(P>0.05);与结直肠癌非转移组患者相比,结直肠癌转移组患者血清MMP-2和MMP-7的浓度显著升高(MMP-2:P=0.029;MMP-7:P=0.002)。结论:基质金属蛋白酶可能在结直肠癌的发生、发展过程中起重要作用;MMP-2和MMP-7可能成为结直肠癌发生和转移的预测和评估指标。
Objective: To investigate the serum matrix metalloproteinase level in patients with colorectal cancer and its clinical significance. Methods: Bio-plex200 suspension chip system was used to detect the expression of matrix metalloproteinase (MMP) in 33 patients with colorectal cancer (13 patients with metastatic colorectal cancer and 20 patients with non-metastatic colorectal cancer) and 30 normal controls ) -1,2,3,7,8,9,10,12,13. Results: Compared with the normal control group, the concentrations of MMP-2, MMP-7, MMP-8, MMP-9, MMP-10 and MMP-13 were significantly increased in patients with colorectal cancer (P < 1, MMP-3 and MMP-12 were not significantly different (P> 0.05). Compared with non-metastasis colorectal cancer patients, the serum concentrations of MMP-2 and MMP-7 in patients with metastasis of colorectal cancer were significantly higher (MMP-2: P = 0.029; MMP-7: P = 0.002). Conclusion: Matrix metalloproteinases may play an important role in the carcinogenesis and progression of colorectal cancer. MMP-2 and MMP-7 may be the predictors of colorectal carcinogenesis and metastasis.