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目的 :探讨大鼠运动病敏感性与血浆皮质醇 (CORT)和促肾上腺皮质激素 (ACTH)水平的关系 ,进一步阐明体液因素在运动病发病中的作用。方法 :采用大鼠条件性厌食症 (CTA)做运动病模型。 84只雌性大鼠 ,12只用于正常对照 ;36只用于旋转刺激后大鼠血浆激素水平的测定 (采用放射免疫分析法 ) ;另 36只用于前庭功能锻炼后大鼠血浆激素水平的测定。结果 :大鼠运动病后血浆 CORT和 ACTH水平升高 ,低敏感组血浆 CORT、ACTH水平显著高于高敏感组 (P<0 .0 1) ;功能锻炼后产生适应的高敏感组大鼠运动病后血浆 CORT、ACTH水平与低敏感组 ,但差异无显著性。结论 :运动病与应激有关 ,运动病敏感性与血浆 CORT、ACTH的水平有关
Objective: To investigate the relationship between motion sickness and plasma cortisol (CORT) and adrenocorticotropic hormone (ACTH) levels in rats and further elucidate the role of humoral factors in the pathogenesis of motion sickness. Methods: Conditional anorexia (CTA) was used as a model of motion sickness. 84 female rats, 12 for the normal control; 36 for the rat plasma hormone levels after rotation stimulation (using radioimmunoassay); and the other 36 for the vestibular function of rat plasma hormone levels Determination. Results: The levels of plasma CORT and ACTH increased after exercise, and the levels of plasma CORT and ACTH in low sensitive group were significantly higher than those in high sensitive group (P <0.01). After exercising, the exercise induced high sensitivity group rats After the illness, plasma CORT, ACTH levels and low sensitivity group, but no significant difference. Conclusion: Kinetic disease is related to stress. The sensitivity of motion sickness is related to the level of plasma CORT and ACTH