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前列腺素(以下简称 PG)是最近迅速发展的一类重要化合物,具有广泛的药理作用。特别是 PG 具有刺激子宫收缩、扩张宫颈内口、溶解黄体等作用,而成为一种较有发展前途的节育新药。南京药学院与南京生物化学制药厂用生物合成法试制成功 PGE_2层析纯品和结晶,并于1973年底开始临床试用于治疗性中期妊娠引产,共进行206例,其中失败4例(原因分析见后述),成功率为98.06%。
Prostaglandins (hereinafter referred to as PG) is a recently developed class of important compounds, has a wide range of pharmacological effects. In particular, PG has the role of stimulating uterine contraction, expansion of the cervix in the mouth, lutein dissolution, etc., and become a more promising new birth control medicine. Nanjing Pharmaceutical College and Nanjing Biochemical Pharmaceutical Factory made a successful PGE 2 chromatography pure product and crystallization experiment by biosynthesis method. At the end of 1973, clinical trial was started for therapeutic mid-term pregnancy induced abortion, a total of 206 cases were failed, of which 4 cases failed (for the reason analysis see Described later), the success rate was 98.06%.