目的:比较消化内镜下切除和腹腔镜手术治疗直径<3.5 cm胃间质瘤的疗效和安全性。方法:采用分层抽样法选取2018年1月至2020年1月运城市中心医院收治的直径<3.5 cm胃间质瘤患者100例，摸球法分为两组：对照组(50例)采用腹腔镜手术治疗，观察组(50例)采用消化内镜下切除术治疗。比较两组治疗效果。结果:观察组手术时间为(63.51±13.52)min，短于对照组的(71.24±15.04)min(n t＝2.703，n P＝0.004)；观察组术中出血量为(38.15±2.55)mL，少于对照组的(40.12±3.56)mL(n t＝3.181，n P＝0.001)；观察组术后禁食时间为(20.02±3.85)h，短于对照组的(22.12±2.96)h(n t＝3.058，n P＝0.001)；观察组术后恢复通便时间为(18.61±1.89)h，短于对照组的(20.05±3.13)h(n t＝2.785，n P＝0.003)；观察组住院时间为(6.25±1.96)d，短于对照组的(7.06±1.16)d(n t＝2.515，n P＝0.007)；观察组并发症发生率为4.00%，低于对照组的8.00%(χn 2＝0.177，n P＝0.673)；两组肿瘤危险度分级差异无统计学意义(n Z＝0.386，n P＝0.534)。n 结论:应用消化内镜下切除术治疗直径<3.5 cm胃间质瘤具有手术时间短、出血少、术后恢复快等优势。“,”Objective:To compare the efficacy and safety of endoscopic digestive resection and laparoscopic surgery in the treatment of gastric stromal tumor with diameter<3.5 cm.Methods:Stratified sampling was used to select 100 patients with diameter<3.5cm gastric stromal tumor from January 2018 to January 2020 in Yuncheng Central Hospital, and they were divided into two groups by touching the ball method.The control group (50 cases) was treated with laparoscopic surgery, and the observation group (50 cases) was treated with digestive endoscopic resection.The therapeutic effects of the two groups were compared.Results:The operative time of the observation group was (63.51±13.52)min, which was shorter than that of the control group [(71.24±15.04)min] (n t=2.703, n P=0.004). The intraoperative blood loss in the observation group was (38.15±2.55)mL, which was less than that in the control group [(40.12±3.56)mL] (n t=3.181, n P=0.001). The postoperative fasting time of the observation group was (20.02±3.85)h, which was shorter than that of the control group [(22.12±2.96)h] (n t=3.058, n P=0.001). The postoperative recover defecation time of the observation group was (18.61±1.89)h, which was shorter than that of the control group [(20.05±3.13)h] (n t=2.785, n P=0.003). The length of hospital stay in the observation group was (6.25±1.96)d, which was shorter than that in the control group [(7.06±1.16)d] (n t=2.515, n P=0.007). The incidence of complications was 4.00% in the observation group, and 8.00% in the control group, the difference between the two groups was statistically significant(χn 2=0.177, n P=0.673). There was no statistically significant difference in tumor risk classification between the two groups (n Z=0.386, n P=0.534).n Conclusion:Endoscopic digestive resection in the treatment of gastric stromal tumor with diameter<3.5cm has advantages of short operation time, less bleeding and fast postoperative recovery, etc., and has certain efficacy and safety.