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转化生长因子-β(TGF-β)是功能复杂的细胞因子,机体内乎所有的细胞或组织都能合成和释放TGF-β并表达其相应受体。近年来发现,TGF-β与肿瘤的发生发展有密切的关系,且其与肿瘤发生发展的关系已成为当今研究的热点。研究证实,在肝癌、大肠癌、乳腺癌、白血病等恶性肿瘤癌组织中存在TGF-β的过度表达,且其表达程度与肿瘤的恶性程度具有相关性。而TGF-β在妇科肿瘤方面的研究尚不多见,本文就TGF-β的结构、功能及其在妇科肿瘤中的研究进展予以综述。
Transforming growth factor-β (TGF-β) is a complex cytokine. All cells or tissues in the body synthesize and release TGF-β and express their corresponding receptors. In recent years, it has been found that TGF-β is closely related to the occurrence and development of tumors, and its relationship with tumorigenesis has become a hot spot in the research. Studies have confirmed that in the liver cancer, colorectal cancer, breast cancer, leukemia and other malignant tumors exist TGF-β overexpression, and its expression level and the degree of malignancy has a correlation. The study of TGF-β in gynecological oncology is still rare, this article reviews the structure and function of TGF-β and its research progress in gynecologic oncology.