目的通过对16 231例育龄夫妇孕前外周血染色体筛查,给染色体核型异常的夫妇予优生指导,减少新生儿出生缺陷的发生。方法对16231例育龄夫妇进行染色体核型分析,确定异常核型。结果 16231例受检者发现异常染色体239例,异常率为1.48%结论孕前染色体筛查,可有效预防遗传缺陷患儿出生,对提高人口素质具有意义。 Objective To screen prenatal chromosomes of 16 231 pregnant women of pre-term pregnancy and to give prenatal guidance to couples with abnormal karyotype, so as to reduce the birth defects of neonates. Methods Chromosomal karyotype analysis was performed on 16,231 couples of childbearing age to identify abnormal karyotypes. Results A total of 16231 cases of abnormal chromosomes were detected in 239 cases, with an abnormality rate of 1.48%. Conclusion Chromosome screening before pregnancy can effectively prevent the birth of children with genetic defects and has significance for improving population quality.