激素替代疗法(HRT)是目前预防而且可能也是治疗绝经后妇女骨质疏松的主要药物之一。虽然近来对雌激素替代疗法增加乳腺癌的危险性注意颇多,但临床医师普遍认为HRT 可使心血管疾病的危险性降低50％,单用雌激素治疗时主要表现在血清脂质尤其是HDL 的有益增加。美国 Lobo 教授认为,理论上雌激素替代疗法可使65～74岁的妇女每100000人死亡数下降366。丹麦研究者使用雌二醇2mg 和醋酸炔诺酮(NETA)1mg对18名绝经较早的患者连续治疗5年,结果发现除了对骨骼产生有益作用外,雌激素/孕激素疗法还显著降低总胆固醇和 LDL,平均约下降20％,对照组则无变化。LDL 下降20％,预示冠心病危险性可减少40％。他们 Hormone replacement therapy (HRT) is currently one of the primary prophylactic and may also be the treatment of osteoporosis in postmenopausal women. Although the recent estrogen replacement therapy to increase the risk of breast cancer, a lot of attention, but clinicians generally believe that HRT can reduce the risk of cardiovascular disease by 50%, estrogen therapy mainly in the serum lipid, especially HDL Beneficial increase. Professor Lobo of the United States believes that in theory, estrogen replacement therapy can reduce the number of deaths per 100000 people aged 65-74 years by 366. Danish researchers treated estradiol 2mg and NETA 1mg for 18 consecutive years of early menopause for 5 years and found that estrogen / progestin therapy significantly reduced the total Cholesterol and LDL, an average reduction of about 20%, the control group did not change. A 20% decrease in LDL indicates a 40% reduction in the risk of coronary heart disease. they