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目前一般认为,外源性3＇,5＇-cAMP可抑制溶质和溶液在不同上皮部位(如小肠上皮、膀胱上皮和肾上皮)的重吸收。此外,在哺乳类动物近曲肾小管,肽类激素(如甲状旁腺素和降钙素)可增加细胞内cAMP的生成,从而抑制钠和水的重吸收,结果与钠偶联的转运过程减弱。cAMP所诱导的这种抑制作用,可能是由于细胞膜通透性的改变和/或由于细胞间屏障的泵机制改变所致。cAMP能使细胞膜的通透性发生改变是一已知事实,但cAMP对肾近曲小管管周细胞的膜电
It is generally accepted that the exogenous 3 ’, 5’-cAMP inhibits reabsorption of solutes and solutions at different epithelial sites such as the small intestine epithelium, bladder epithelium, and renal epithelium. In addition, proximal tubular, peptide hormones (such as parathyroid hormone and calcitonin) in mammals increase intracellular cAMP production, thereby inhibiting sodium and water reabsorption, resulting in sodium-coupled transport Weakened. This inhibitory effect induced by cAMP may be due to changes in cell membrane permeability and / or due to changes in the pump mechanism of the intercellular barrier. It is a known fact that cAMP can alter the permeability of the cell membrane, but the membrane potential of cAMP to the proximal tubules of the kidney