脑水肿是神经系统疾病的基本病理过程,与神经系统疾病治疗关系密切,血脑屏障(BBB)为脑组织与外界进行营养物质交流的系统,它保证了中枢神经组织内环境的稳定。血脑屏障的损伤在脑水肿的发生发展中起重要作用。研究表明,多重因素参与了BBB结构功能的改变和破坏,而BBB结构功能的变化是脑水肿病理变化的重要环节。探讨影响血脑屏障通透性的因素,可为临床治疗方案的优化提供理论依据。 Brain edema is the basic pathological process of nervous system diseases and closely related to the treatment of nervous system diseases. The BBB is a system for the exchange of nutrients between the brain tissue and the outside world, which ensures the stability of the environment inside the central nervous system. Blood-brain barrier injury plays an important role in the development of cerebral edema. Studies have shown that multiple factors involved in the structural changes in BBB damage and destruction, and structural changes in BBB is an important part of the pathological changes of brain edema. To explore the factors affecting the permeability of the blood-brain barrier may provide a theoretical basis for the optimization of clinical treatment options.