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由于重症患者生理病理情况的特殊性,药物在其体内的药代动力学/药效学(PK/PD)参数改变较大,难以预测。当β内酰胺类抗生素用于重症患者抗感染治疗时,若按照指南、说明书和经验用药的推荐剂量用药,常会出现剂量不足或药物不良反应等情况,治疗药物监测(TDM)是优化重症患者抗生素使用的重要手段之一。本文将对2010-2016年有关重症患者使用β内酰胺类抗生素进行抗感染治疗的情况及其TDM现状作一综述。
Because of the special physiological and pathological conditions of critically ill patients, pharmacokinetics / pharmacodynamics (PK / PD) parameters of the drug in the body vary greatly and are difficult to predict. When beta-lactam antibiotics are used in anti-infective therapy in critically ill patients, dosing or drug adverse reactions often occur when the recommended doses of the beta-lactam antibiotics are used according to the guidelines, instruction manuals, and empirical medication. TCD is an option to optimize antibiotics in critically ill patients One of the important means of use. This article reviews the 2010-2016 anti-infective treatment of critically ill patients with beta-lactam antibiotics and their current status of TDM.