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目的研究纳洛酮在临床治疗中的量效关系。方法选取2011年2月-2015年2月收治的100例脑梗死患者,随机分为四组,每组25例,分别给予1.2mg、2.4mg、3.6mg、5.8mg剂量的纳洛酮进行治疗,以15d为一个疗程,观察观察一个疗程后的疗效。结果 1.2mg组基本无效;2.4mg组处于量效关系的上升阶段;3.6mg组具有良好的治疗效果,但与5.8mg之间无明显差异。结论纳洛酮治疗脑梗死最佳剂量在3.6mg到5.8mg范围之内。
Objective To study the dose-response relationship of naloxone in clinical treatment. Methods A total of 100 patients with cerebral infarction who were admitted from February 2011 to February 2015 were randomly divided into four groups with 25 patients in each group and received naloxone 1.2mg, 2.4mg, 3.6mg and 5.8mg respectively , To 15d for a course of treatment, observe the effect of a course of treatment. Results 1.2mg group basically ineffective; 2.4mg group in the rising stage of the dose-effect relationship; 3.6mg group has a good therapeutic effect, but no significant difference between 5.8mg. Conclusion The best dose of naloxone for cerebral infarction is in the range of 3.6mg to 5.8mg.