论文部分内容阅读
目的探讨系统超声检查在胎儿先天畸形筛查中的价值。方法对2081例胎儿先后进行常规产科B超检查和系统超声检查,以临床特征、染色体检查和尸检结果为依据,判定胎儿是否患有先天畸形,并以此确诊结果为金标准。观察比较两种筛查方法的灵敏度、特异性、阳性预测值和阴性预测值。结果与金标准对照发现,常规产科B超误诊19例、漏诊10例,系统超声检查误诊4例、漏诊1例。系统超声的灵敏度、特异性、阳性预测值和阴性预测值分别为95.24%、99.81%、83.33%和99.95%,均显著优于常规B超的52.38%、99.08%、36.67%和99.51%,差异具有统计学意义(P<0.05)。结论系统超声检查在胎儿先天畸形筛查中运用,有助于提高胎儿先天畸形的检出率,降低漏诊率,具有推广意义。
Objective To investigate the value of systematic ultrasound in the screening of fetal congenital malformations. Methods A total of 2081 fetuses were followed up by conventional B-mode ultrasonography and systematic ultrasound examination. Based on the clinical features, chromosomal examination and autopsy results, the fetus was diagnosed with congenital malformations and the result of diagnosis was the gold standard. The sensitivity, specificity, positive predictive value and negative predictive value of the two screening methods were observed and compared. Results and gold standard control found that conventional obstetrics B-misdiagnosis in 19 cases, 10 cases of missed diagnosis, 4 cases of misdiagnosis of the system ultrasound, 1 case of missed diagnosis. The sensitivity, specificity, positive predictive value and negative predictive value of the ultrasound system were 95.24%, 99.81%, 83.33% and 99.95% respectively, which were significantly better than those of conventional B ultrasound in 52.38%, 99.08%, 36.67% and 99.51% Statistically significant (P <0.05). Conclusion Systemic ultrasound examination in fetal congenital malformation screening, help to improve the detection rate of fetal congenital malformations, reduce the rate of misdiagnosis, has the promotion of significance.