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目的:探讨移居海拔5 100m高原合理用氧方案的研究。方法:对海拔5 100m以上居住3个月以上的60名青年随机分为A组(每天上午和晚上各吸氧1h,n=20),B组(每天上午吸氧1h,n=20),C组(不吸氧,n=20),吸氧流量为2L/min,连续吸氧60天,检测吸氧前后慢性高原病(CMS)症状评分、睡眠质量评分、血红蛋白(Hb)浓度、HR、Sa O2和6min步行距离。结果:吸氧30天和60天较吸氧前A组、B组CMS症状评分、睡眠质量评分、Hb降低,Sa O2、6min步行距离升高,有非常显著性差异,C组Hb增高,有非常显著性差异(P<0.05或P<0.01);吸氧30天较吸氧60天A组和B组CMS症状评分、睡眠质量评分、Hb降低,A组6min步行距离降低,B组Sa O2升高,有显著性差异(P<0.05或P<0.01)。A组较B组吸氧30天和60天CMS症状评分、睡眠质量评分均降低,吸氧60天6min步行距离升高,有显著性差异(P<0.05或P<0.01);A组较C组吸氧30天和60天CMS症状评分、睡眠质量评分降低,Sa O2、6min步行距离升高,有非常显著性差异(P<0.01);B组较C组吸氧30天和60天CMS症状评分、睡眠质量评分均降低,Sa O2、6min步行距离升高,有显著性差异(P<0.05或P<0.01)。结论:每天给予1h和2h低浓度氧疗,可预防慢性高原病,改善高原睡眠质量,提高机体Sa O2,控制血红蛋白浓度增加。早晚各吸1h要优于上午吸氧1h。
Objective: To study the rational use of oxygen in the 5 100 m altitude migration. Methods: Sixty youngsters who lived above 5 100m above sea level for 3 months or more were randomly divided into group A (n = 20 for 1h and n = 20 for morning and evening), group B (oxygen for 1h every morning, n = 20) C group (no oxygen, n = 20), oxygen flow rate of 2 L / min, continuous oxygen 60 days before and after oxygen inhalation test, symptom score, sleep quality score, hemoglobin (Hb) , Sa O2 and 6min walking distance. Results: The symptom scores of CMS, sleep quality score, Hb, Sa O2 and 6-min walk distance in group A at 30 days and 60 days after oxygen inhalation were significantly higher than those in group A (P <0.05 or P <0.01). The scores of CMS, sleep quality score and Hb in group A and group B after 30 days of oxygen inhalation were lower than those in group B Increased, there was significant difference (P <0.05 or P <0.01). The scores of CMS symptom and sleep quality in group A were significantly lower than those in group B (P <0.05 or P <0.01) at 30 days and 60 days, The symptom score of CMS, sleep quality scores decreased on 30th and 60th days after oxygen inhalation in rats, and the walking distance increased in Sa O2 and 6min after the oxygen inhalation (P <0.01) Symptom scores, sleep quality scores were reduced, Sa O2, 6min walk distance increased, there was a significant difference (P <0.05 or P <0.01). Conclusion: 1h and 2h low oxygen therapy can prevent chronic altitude sickness, improve the quality of sleep in high altitude, improve the body’s Sa O2 and increase hemoglobin concentration. 1h sooner or later than the morning to absorb oxygen 1h.