六十年代末Tashian等人发现非特异性的羧酸酯酶A、B、C、后1973年Hopkinson等人利用淀粉凝胶电泳发现了1种具有多态性的酯酯D(Esterase.D,EsD)。分子量为60,000道尔顿,最适pH介于5.0～5.5之间。 EsD的电泳表型有EsD1-1。EsD2-1与EsD2-2型,分别受等位基因EsD~1、EsD~2所控制。以后,相继发现稀有型EsD~3、EsD~4、EsD~5、EsD~6、EsD~0、EsD~7等几种等位基因。均存在于13号染色体上。 EsD的发现和其他同工酶一样。在群体 Tashian et al. Found non-specific carboxylesterase A, B and C in the late 1960s. In 1973, Hopkinson et al. Used starch gel electrophoresis to find a polymorphic Esterrase D (EsD ). The molecular weight is 60,000 daltons and the optimum pH is between 5.0 and 5.5. EsD electrophoresis phenotype EsD1-1. EsD2-1 and EsD2-2, respectively, by the alleles EsD ~ 1, EsD ~ 2 control. Later, several rare alleles such as EsD ~ 3, EsD ~ 4, EsD ~ 5, EsD ~ 6, EsD ~ 0, EsD ~ 7 were found one after another. Both exist on chromosome 13. EsD’s findings are the same as for other isozymes. In groups