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1TGF-β的结构和功能1.1转化生长因子-β(Transforming growth factor-β,TGF-β)是一种可以调节细胞生长,分化和促进细胞外基质形成的多功能多肽,其广泛存在于多种细胞组织中。对转基因动物模型的研究表明,TGF-β介导的信号转导通路在正常乳腺组织和乳腺肿瘤的发生发展过程中起到极其关键的作用。在对于乳腺癌发病机制的研究中,TGF-β表现出具有抑制早期癌变的作用,但是随着肿瘤的发展,这种抑制作用常被逆转进而促进肿瘤的发展,考虑和TGF-β的多效性和对环境的高度依赖性有关TGF-β治疗性调节可能也是众多因素之一。
Structure and function of 1 TGF-β 1.1 Transforming growth factor-β (TGF-β) is a multifunctional polypeptide that can regulate cell growth, differentiation and promote the formation of extracellular matrix, which is widely distributed in many Cell tissue. Studies on transgenic animal models have shown that TGF-β-mediated signal transduction pathway plays an extremely crucial role in the development and progression of normal breast and breast tumors. In the study of the pathogenesis of breast cancer, TGF-β showed the role of inhibiting early canceration, but with the development of the tumor, this inhibition is often reversed and thus promote the development of the tumor, and consider the multi-effect of TGF-β Sexual and Environmentally Dependent Therapeutic regulation of TGF-β may also be one of many factors.