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Ⅰ型变态反应为嗜碱细胞及肥大细胞细胞膜上的反应素与抗原反应的结果,从嗜碱细胞中释放出介质而引起各种变态反应症状。对此种嗜碱细胞的研究,近年来有不少报道。作者们观察了给药前后鼻粘膜表层嗜碱细胞的变化。对93名常年性鼻变态反应患者,从两侧下鼻甲前端刮取粘膜表层标本涂片,以95%甲醇固定5分钟,用Hansel氏液染色40～50秒钟,用400倍镜检。见细胞质中带有异染色颗粒的细胞即为嗜碱细胞,计算细胞数。抗变态反应制剂给药量:(1)抗组织胺药扑尔敏12mg/日,连用7日,共10人;meclastine fumarate 4mg/日,连用7日,共9人。(2)色甘酸钠成人80mg/日
Type I allergic reaction is basophil and mast cell membrane reaction of the elements and antigens results in the release of media from basophils caused by a variety of allergic symptoms. Research on this kind of basophil has been reported in recent years. The authors observed changes in nasal mucosal surface basophils before and after administration. Of 93 patients with perennial nasal allergies, mucosal smear specimens were scraped off from the inferior turbinate on both sides, fixed in 95% methanol for 5 minutes, stained with Hansel’s solution for 40 to 50 seconds, and examined microscopically at 400-fold. See cells with heterochromatic particles in the cytoplasm that is basophils, count the number of cells. Anti-allergic agents Dosage: (1) antihistamine chlorpheniramine 12mg / day, once every 7 days, a total of 10 people; meclastine fumarate 4mg / day, once every 7, a total of 9 people. (2) cromolyn adult 80mg / day