论文部分内容阅读
目的探讨食管癌患者外周血红细胞分布宽度(RDW)检测的临床价值。方法回顾性分析山东大学附属省立医院在2010年7月~2011年6月接受根治性手术切除的284例食管癌患者的临床资料。收集125例健康志愿者作为对照进行对比分析;采用受试者工作特征曲线(ROC曲线)确定RDW最佳截断点,将患者分为高RDW组和低RDW组,比较两组间的临床病理参数;采用Logistic回归分析与RDW增高有关的临床病理参数;分析手术治疗前后RDW值变化。结果食管癌组患者RDW的中位数显著高于健康对照组(P<0.001);RDW与食管癌组患者性别、年龄、远处转移和肿瘤分期有关(P<0.05),而与其他病理参数无关(P>0.05);Logistic回归分析发现高龄和远处转移与RDW升高有关(P<0.05);手术治疗后RDW的值高于治疗前,差异有统计学意义。结论RDW可作为食管癌患者临床诊断及病情评估的指标。
Objective To investigate the clinical value of peripheral blood red blood cell distribution width (RDW) detection in patients with esophageal cancer. Methods The clinical data of 284 esophageal cancer patients undergoing radical surgical resection from July 2010 to June 2011 at Provincial Hospital Affiliated to Shandong University were retrospectively analyzed. 125 healthy volunteers were collected as a control for comparative analysis; the best cutoff point of RDW was determined by receiver operating characteristic curve (ROC curve), and the patients were divided into high RDW group and low RDW group. The clinicopathological parameters Logistic regression analysis was used to analyze the clinicopathological parameters related to the increase of RDW. The changes of RDW before and after operation were analyzed. Results The median RDW in esophageal cancer patients was significantly higher than that in healthy controls (P <0.001). RDW was associated with gender, age, distant metastasis and tumor stage (P <0.05), but not with other pathological parameters (P> 0.05). Logistic regression analysis showed that the elderly and distant metastasis were associated with the increase of RDW (P <0.05). The RDW value after operation was higher than that before treatment, the difference was statistically significant. Conclusion RDW can be used as an index of clinical diagnosis and disease evaluation in patients with esophageal cancer.