在本期周刊中,菲利普斯等人对6个患有胆汁淤积的北美克里族儿童肝脏中锌和铜过量进行了报道,锌既沉积于肝细胞中也沉积于肝小管中。电子显微镜技术显示锌损害小管周围的肌动蛋白。胆汁淤积的肝脏中锌含量高得惊人,远远高于无胆汁淤积对照组的2个肝脏(一个是肝小管闭锁,一个是威尔森氏症)。菲利普斯等人认为过量锌可能已经导致胆汁淤积;他们还认为是他们首先得 In this issue of the issue, Phillips et al. Report on zinc and copper excess in the liver of six Cholestatic North American Kill children, both deposited in hepatocytes and deposited in the liver tubules. Electron microscopy shows that zinc damages actin around the tubules. Cholestatic liver zinc levels were staggering, well above the 2 livers of the cholestatic control group (one with hepatic atresia and one with Wilson’s disease). Phillips et al. Think that excess zinc may have caused cholestasis; they also think they are the first to have