中国是乙肝大国,肝纤维化是多种慢性肝病发展至肝硬化的必经阶段,肝细胞、内皮细胞、枯否细胞等能够通过产生转化生长因子、血小板衍生生长因子、肝细胞生长因子、肿瘤坏死因子等细胞因子直接或间接地促进肝星状细胞(HSC)活化,继而原癌基因和核因子等转录因子被激活,导致HSC增 China is a major hepatitis B country. Liver fibrosis is a necessary stage for the development of a variety of chronic liver diseases to cirrhosis. Hepatocytes, endothelial cells, Kupffer cells and the like can be differentiated by producing transforming growth factor, platelet-derived growth factor, hepatocyte growth factor, Cytokines such as necrosis factor directly or indirectly promote hepatic stellate cell (HSC) activation, and then transcription factors such as proto-oncogenes and nuclear factor are activated, leading to increased HSC